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Keep in mind that ibuprofen and other nonsteroidal anti-inflammatory drugs … However, taking it with certain medications and substances can cause unintended—and sometimes dangerous—side effects. · understand how to safely pair benzonatate with other medications and substances to prevent adverse effects. Yes there are no significant interactions. Benzonatate is contraindicated in individuals with known hypersensitivity or allergies to the drug. · benzonatate should not be taken with mao inhibitors, sedatives, or other medications that cause drowsiness. These medicines may also interact with certain foods or diseases. · benzonatate (sold under the brand name tessalon) is a nonopioid prescription cough suppressant that numbs the airways to help reduce the cough reflex. Common drug interactions include dyspnoea among females and anxiety … · it’s generally safe to take benzonatate with acetaminophen (tylenol) or ibuprofen (advil, motrin). Drug interactions are reported among people who take advil (ibuprofen) and benzonatate (benzonatate). Benzonatate may also interact with other drugs that are not listed here. · get the best care from a doctor who knows you. Before taking benzonatate, it is important to talk to a doctor about all medications, vitamins, and herbal supplements that are being taken. View drug interactions between advil and benzonatate. It is generally safe to take over-the-counter pain relievers like ibuprofen or acetaminophen (tylenol) alongside benzonatate to manage symptoms such as fever or body aches. It should also be used with caution in patients with pre-existing conditions like kidney or liver …