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It is now possible to browse by project and download complete datasets for all available products and genome versions for the current and 3 previous releases – cosmic, cell lines project, actionability, and cancer mutation census (cmc). Cosmic mutational signatures is a catalogue of curated reference mutational signatures. Please contact us via cosmic@sanger. ac. uk if you encounter any issues. This is the cosmic downloads page. Starting on april 2nd, existing users must re-register upon their first visit to continue using our web platform. Curation covers aetiology, acceptance criteria, tissue distribution and other genomic features of each mutational signature. Cosmic, the catalogue of somatic mutations in cancer, is the worlds largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Downloadable signature profiles and other data are freely available. The aim of cosmic mutation actionability in precision oncology product (actionability) is to indicate the availability of drugs that target mutations in cancer and track the progress of clinical studies towards making new drugs available. · cosmic-3d integrates cancer mutations with protein structures across the human genome and structural proteome. Our unique combination of protein structure, mutation location/recurrence, and druggability predictions presents a vital tool for precision medicine, enabling high-resolution mutation-guided drug discovery. This registration process only needs to be completed once: To complete this step, login and you will be redirected to our re-registration page.
