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Report that hypoxia and inflammatory cytokines activate the stat3/integrin β3 axis, promoting stress tolerance and accelerating pancreatic cancer … · pancreatic ductal adenocarcinoma (pdac) is a highly aggressive cancer with a poor prognosis which is lethal in over 90% of cases despite the standard therapies. Signal transducer and activator … In this review, the current knowledge of stat3 in pancreatic cancer has been summarized, particularly relating to stat3 activation in cancer cells, cells of the tme, and the state of … There remain prominent gaps in the current understanding of the disease, specifically … · the key role of stat3 in promoting pancreatic cancer progression has been proven, but effective interventions that suppress stat3 activities are limited. Abstract pancreatic cancer remains a serious and deadly disease, impacting people globally. Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. · campos and shepard et al. · signal transducer and activator of transcription 3 (stat3), a downstream pathway of sting, is notably overexpressed in pancreatic cancer and related to tumor survival and … Though only a few trials have shown the efficacy in a clinical setting, the stat3 pathway remains a promising drug target for future treatment of pancreatic ductal adenocarcinoma and may …
