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· deep learning has advanced the design of static protein structures, but the controlled conformational changes that are hallmarks of natural signaling proteins have remained … · science is the leading multidisciplinary, international journal of peer-reviewed research including analysis and news coverage of breakthroughs and policy. · the gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (mash). In this work, we report an hlb resistance regulatory circuit in citrus composed of an e3 ubiquitin ligase, pub21, and its … The thermal stability of the cu … · huanglongbing (hlb) is a devastating citrus disease. · present vision restoration technologies have substantial constraints that limit their application in the clinical setting. We analyzed a global database of soil pollution by arsenic, cadmium, cobalt, chromium, copper, … · science/aaas peer-reviewed journals deliver impactful research, daily news, expert commentary, and career resources. · toxic metal pollution is ubiquitous in soils, yet its worldwide distribution is unknown. · we present a bulk nanocrystalline copper alloy that can operate at near-melting temperatures with minimal coarsening and creep deformation. Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life … A neuromorphic e-skin system simultaneously emulates closed-loop sensory encoding and mechanical softness of natural skin. In this work, we fabricated a subretinal nanoprosthesis using …